Biosensor design
نویسندگان
چکیده
منابع مشابه
Design of a ribonucleopeptide biosensor.
Ribonucleopeptide receptors for ATP have been designed by using a structure-based design and in vitro selection method. The ATP binding ribonucleopeptide receptors revealed submillimolar affinity to ATP and discriminate ATP against other ribonucleotides. In this research, we have developed a simple strategy to convert the ATP-binding ribonucleopeptide receptor into a ribonucleopeptide sensor by...
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In this study the repressor of Escherichia coli lac operon, LacI, has been engineered for altered effector specificity. A LacI saturation mutagenesis library was subjected to Fluorescence Activated Cell Sorting (FACS) dual screening. Mutant LacI-L5 was selected and it is specifically induced by lactulose but not by other disaccharides tested (lactose, epilactose, maltose, sucrose, cellobiose an...
متن کاملDesign requirements for integrated biosensor arrays
Miniaturization and integration of biosensor platforms is appealing due to smaller reaction volumes, larger numbers of detection sites and integration of various functionalities. Proper design of integrated biosensors is crucial in such systems due to limitation in resources such as power, chip area and cost. The optimal design involves determining the required sensor metrics and achieving thes...
متن کاملDesign of acetylcholinesterases for biosensor applications.
In recent years, the use of acetylcholinesterases (AChEs) in biosensor technology has gained enormous attention, in particular with respect to insecticide detection. The principle of biosensors using AChE as a biological recognition element is based on the inhibition of the enzyme's natural catalytic activity by the agent that is to be detected. The advanced understanding of the structure-funct...
متن کاملBiosensor Design through Molecular Dynamics Simulation
Abstract—The beginning of 21st century has witnessed new advancements in the design and use of new materials for biosensing applications, from nano to macro, protein to tissue. Traditional analytical methods lack a complete toolset to describe the complexities introduced by living systems, pathological relations, discrete hierarchical materials, cross-phase interactions, and structure-property ...
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ژورنال
عنوان ژورنال: Nature
سال: 2003
ISSN: 0028-0836,1476-4687
DOI: 10.1038/423132a